Smart Delivery Systems Responsive to Cathepsin B Activity for Cancer Treatment

Cathepsin B is a lysosomal cysteine protease, contributing to vital cellular homeostatic processes including protein turnover, macroautophagy of damaged organelles, antigen presentation, and in the extracellular space, it takes part tissue remodeling, prohormone processing, activation. However, aberrant overexpression cathepsin its enzymatic activity associated with different pathological conditions, cancer. tumor tissues makes this enzyme an important target for smart delivery systems, responsive enzyme. The generation technologies which therapeutic effect activated as result cleavage provides opportunity tumor-targeted therapy controlled drug release. In review, we summarized designed improve current cancer treatments that were shown play key role disease progression response treatment.